January 3, 2008
Interesting – if GnRH antagonist can block cellular division and decrease the secretion of E2 from the ovaries, could this be a part of the mechanism of increasing the follicular phase in the preceding article? Often we only think drugs have a singular effect, GnRH antagonist should only effect pituitary, yet GnRH receptors exist in the ovaries/follicles and play an important role in embryonic growth. If GnRH has a role in cellular replacement/growth, then could some problems with embryonic quality be related to drugs blocking important hormonal receptors?
From a Chinese perspective GnRH would be considered a qi mover. Qi movers help to keep energy flowing and transforming. An example would be electricity coming through the outlet and into the plug. It flows without any resistance and moves into the appliance. Once the electricity enters into the appliance, it is transformed into an action, such as light, heat, cool air or a picture. When one part of the action fails, it effects the other. In a trying to conceive, emotional stress can constrict/block qi causing menstrual irregularities, intense PMS and a lack of libido. If a basic hormone (GnRH) plays an important role in moving qi, could acupuncture/Chinese herbs improve the body’s ability to utilize it correctly resulting in pregnancy? Maybe future research will investigate.
Early cleavage does not predict treatment outcome following the use of GnRH antagonists in women older than 35
Volume 88, Issue 6, Pages 1573-1578 (December 2007)
Wen-Jui Yang, M.D.a, Yuh-Ming Hwu