PCOS, Part Three
Coming Soon.
PCOS: What is going wrong? Part 2, continued
Increases FSH Receptors and Estradriol Release
Whether increased granulosa cell sensitivity to FSH arises primarily from the ovary or secondarily as a result of non ovarian factors is unknown. Studies have shown that granulosa cells from PCOS have greater binding of FSH compared with normal ovaries.
1. FSH Receptor Hyper-responsiveness and Hyperstimulation
Despite a lack of ovulation, studies have demonstrated that PCOS granulosa cells are extremely sensitive to follicle-stimulating hormone (FSH) stimulation when compared with normal cells.Studies find women with PCOS have estradiol secretion in response to FSH (during stimulation) that is comparable to normal women. Yet, beyond a certain threshold […]
PCOS: What is going wrong? Part 2, continued
Increases FSH Receptors and Estradriol Release
Whether increased granulosa cell sensitivity to FSH arises primarily from the ovary or secondarily as a result of non ovarian factors is unknown. Studies have shown that granulosa cells from PCOS have greater binding of FSH compared with normal ovaries.
1. FSH Receptor Hyper-responsiveness and HyperstimulationDespite a lack of ovulation, studies have demonstrated that PCOS granulosa cells are extremely sensitive to follicle-stimulating hormone (FSH) stimulation when compared with normal cells. Studies find women with PCOS have estradiol secretion in response to FSH (during stimulation) that is comparable to normal women. Yet, beyond a certain threshold of […]
PCOS: What is going wrong? Part 2
My previous article described the basic theory behind follicular growth.With that basic theory we can look at what is can happen when hormones and receptors don’t work properly. The following information comes from the article “The reproductive phenotype in polycystic ovary syndrome” by R Jeffrey Chang.I have changed some of the wording to simplify concepts, but if you want to read the article the in its’ originality go to:http://www.nature.com/ncpendmet/
journal/v3/n10/full/ncpendmet0637.html
1) Follicles Unable to Fully Mature. Normal follicle development involves pre-antral growth of the primordial follicle (containing an immature oocyte surrounded by a single layer of […]