Infertility

As usual, the journal Fertility and Sterility has tons of interesting research. This particular article grabbed my attention, since every year one of my clients will have problems with hyperstimulation. The article discusses the use of a GnRH agonist (encourages the pituitary to secret higher levels of FSH/LH) as the trigger before retrieval.  Most IVF cycles use HCG (identical to FSH/LH) as the trigger, which has a long half life (it lingers for a long time in the blood stream before the body can eliminate it) and it can encourage the continual growth of follicles.

OHSS is serious consequence of IVF, […]

Coming Soon.

Increases FSH Receptors and Estradriol Release

Whether increased granulosa cell sensitivity to FSH arises primarily from the ovary or secondarily as a result of non ovarian factors is unknown. Studies have shown that granulosa cells from PCOS have greater binding of FSH compared with normal ovaries.

1. FSH Receptor Hyper-responsiveness and Hyperstimulation

Despite a lack of ovulation, studies have demonstrated that PCOS granulosa cells are extremely sensitive to follicle-stimulating hormone (FSH) stimulation when compared with normal cells.Studies find women with PCOS have estradiol secretion in response to FSH (during stimulation) that is comparable to normal women. Yet, beyond a certain threshold […]

Increases FSH Receptors and Estradriol Release

Whether increased granulosa cell sensitivity to FSH arises primarily from the ovary or secondarily as a result of non ovarian factors is unknown. Studies have shown that granulosa cells from PCOS have greater binding of FSH compared with normal ovaries.

1.  FSH Receptor Hyper-responsiveness and HyperstimulationDespite a lack of ovulation, studies have demonstrated that PCOS granulosa cells are extremely sensitive to follicle-stimulating hormone (FSH) stimulation when compared with normal cells. Studies find women with PCOS have estradiol secretion in response to FSH (during stimulation) that is comparable to normal women.   Yet, beyond a certain threshold of […]